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Protective Roles of Grape-derived Polyphenols in Alzheimer’s Disease

National Center for Complimentary and Alternative Medicine (NCCAM). In this consortium, led by the Mount Sinai School of Medicine, NYC (G. Pasinetti, MD, Ph.D., lead CREC PI at Mt. Sinai) with collaborating organizations at Purdue University (M. Ferruzzi, E. Janle, C. Weaver), Nobel Foundation (R. Dixon), Albert Einstein School of Medicine (P. Marambaud ), Texas A&M (S. Talcott) and Rutgers University. At Rutgers, Prof. Simon and Wu, lead this work at Rutgers in which several of our graduate students are heavily involved including: Thomas Villani, Cara Welch (former student) and Adolfo Pertuz. Our role is centered in Core B: The Botanical and Analytical Core, in which our major role is the chemical characterization of bioactive compounds and product standardization for biological studies. More specifically, this has involved the support the individual CERC projects by facilitating the chemical characterization of grape juice/wine

(Project 1); grape seed extract.
(Project 2) to target tissues.
(Project 3) polyphenol fractions and; to determine bioavailability, metabolism and distribution of grape polyphenols including resveratrol.

Rutgers and Purdue are both involved in the characterization, archival and assessment of in vivo polyphenol bioavailability from grape fractions. This work is supported by a grant from the National Institute of Health. National Botanical Center. Center for Excellence in Research on Alzheimers Disease. NIH Award 1 PO1 AT004511-01A.


2023. Tambe, M.A., A. de Rus Jacquet, K.E. Strathearn, G.G. Yousef, M.H. Grace, M.G. Ferruzzi, Q.L. Wu, J.E. Simon, M.A. Lila and J.C. Rochet. Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson’s disease. Antioxidants 12(7):1463. Doi: 10.3390/antiox12071463.

2021. Lyu, W., D. Rodriguez, M. Ferruzzi, G.M. Pasinetti, J.W. Murrough, J.E. Simon and Q.L. Wu. Chemistry, Manufacturing and Standardization Controls of Grape Polyphenol Dietary Supplements for Support of a Clinical Study: Mass Uniformity, Polyphenol Dosage and Profile. Frontiers in Nutrition: 8:780226. doi: 10.3389/fnut.2021.780226

2021. Lyu, W., T. Omar, H. PatelG, D. Rodriguez, M.G. Ferruzzi, G.M. Pasinetti, J.W. Murrough, F.J. Muzzio, J.E. Simon and Q.L. Wu. Dissolution Study of Grape Polyphenol Hard Gelatin Capsule Dietary Supplements. Frontiers in Nutrition: 8:780260. doi: 10.3389/fnut.2021.780260

2022. Van Doren, W.W., U.H. Iqbal, D.A. Helmer, D.R. Litke, J.E. Simon, Q.L. Wu, D. Zhao, Z. YinG, L. Ho, O. Osinubi and G.M. Pasinetti. Changes in polyphenol serum levels and cognitive performance after dietary supplementation with Concord grape juice in veterans with Gulf War Illness. Journal Life Science 119797: DOI: 10.1016/j.lfs.2021.119797

2020. Zhao D.Y., J.E. Simon and Q.L. Wu. A Critical Review on Grape Polyphenols for Neuroprotection: Strategies to Enhance Bioefficacy. Critical Reviews in Food Science and Nutrition 60(4):597-625 (Review paper).

2005. Wu, Q.-L., Mingfu Wang and James E. Simon. Determination of proanthocyanidins in fresh grapes and grape products using liquid chromatography with mass spectrometric detection. Rapid Communications in Mass Spectrometry 19: 2062-2068.

2003. Wu, Q.L., M. Wang and J.E. Simon. Determination of proanthacyanidins in grape products by LC/MSD under low collision energy, Analytical Chemistry 75:2440-2444.