A. annua was traditionally used in ancient Chinese medicine as a fever reducer, more recently it has been studied for anti-malarial and anti-cancer treatments. Our lab developed a liquid chromatography−mass spectrometry (LC-MS) method with selected ion monitoring (SIM) and validated it for the analysis and standardization of artemisinin in Artemisia annua.
2005. Wang, M., C.H. Park, Q. Wu, and J.E. Simon. Analysis of artemisinin in Artemisia annua L. by LC-MS with selected ion monitoring. Journal Agric. Food Chem. 53: 7010-7013.
2005. Benge, M, G. Cragg, J. Duke, J. Ferreira, J. Hopper, W.J. Kress, J.E. Simon, A. Weil, M.L. Wilcox. Responding to: Malaria Fight: Gates Foundation funds development of malaria drug artemisinin and January 3, 2005, BOOTSTRAPPING VIA PHILANTHROPY: A Californian start-up chooses a zero-profit project: helping to develop a malaria drug. Chemical Engineering News, March 01, 2005. This letter to the editor requests studies on standardized plant extracts of A. annua for the treatment of malaria.
1997. Ferreira, J.F.S., J.E. Simon and J. Janick. Artemisia annua L.: Botany, Horticulture and Pharmacology. In: Janick, J. (ed). Horticultural Reviews 19:319-371.
1995a. Ferreira, J. J.E. Simon, and J. Janick. Developmental studies of Artemisia annua L.: Flowering and artemisinin production under greenhouse and field conditions. Planta Medica: 61:167-170.
1995b. Ferreira, J. J.E. Simon, and J. Janick. Relationship of artemisin content of tissue-cultured, greenhouse-grown, and field-grown plants of Artemisia annua L. Planta Medica: 61:351-355.
1994. Ferreira, J.F.S., D.J. Charles, K. Wood, J. Janick and J.E. Simon. A comparison of gas chromatography and high performance liquid chromatography for artemisinin analyses. Phytochemical Analysis 5:116-120.
1993. Morales, M.R., Charles, D.J. and J.E. Simon. Seasonal accumulation of artemisinin in Artemisia annua L. Internatational Symposium on Medicinal and Aromatic Plants, March 22-25, 1993, Tiberias, Israel. Acta Horticulturae 344: 416-420.
1993. Charles, D.J., J.E. Simon, C.C. Shock, E.B.G. Feibert and R.M. Smith. Effect of water stress and drying on artemisinin content in the leaves of Artemisia annua L., pp. 640-643. In: J. Janick and J.E. Simon (eds). New Crops: New Crops: Exploration, Research, Commercialization. Proc. New Crops, Oct. 6-9, 1991, Indianapolis, IN. John Wiley & Sons, Inc., N. Y.
1992. Whipkey, A., J.E. Simon, D.J. Charles and J. Janick. In vitro production of artemisinin from Artemisia annua L. J. Herbs, Spices and Medicinal Plants 1:15-25.
1991. Charles, D.J., E. Cebert and J.E. Simon. Characterization of the essential oil of Artemisia annua L. J. Essential Oil Research 3:33-39.
1990. Charles, D.J. and J.E. Simon, K.V. Wood and P. Heinstein. Germplasm variation in artemisinin content of Artemisia annua using an alternative method of artemisinin analysis from crude plant extracts. J. Natural Products. 53(1):157-160
1990. Simon, J.E., D.J. Charles, E. Cebert, L. Grant, J. Janick and A. Whipkey. Artemisia annua L.: A promising aromatic and medicinal. Advances in New Crops, Timber Press, Portland, OR. pp. 522-526.